Healthcare investing: what investors need to know

Healthcare is home to some of the world’s most important innovations, from new cancer treatments to weight-loss medicines. But for investors, it can also be a complex sector to understand. CT Healthcare Trust aims to help investors access long-term opportunities in healthcare through a specialist approach that combines scientific insight, commercial experience and careful risk management.

Healthcare is changing lives — and markets

Healthcare innovation can have a major impact on people’s lives. Breakthroughs in areas such as cancer treatment, gene-based therapies and weight-loss medicines are changing standards of care and creating new investment opportunities. However, the sector is not simply about backing the next exciting discovery. For investors, the challenge is understanding which companies have the strongest chance of turning scientific progress into sustainable businesses.

Why healthcare can be difficult to navigate

Healthcare is a specialist area. Company valuations can change quickly in response to clinical trial results, regulatory decisions or changes in the competitive landscape. Some companies may benefit significantly from successful product development, while others may struggle if trials disappoint or approvals are delayed.

This creates both opportunity and risk. Many drug development programmes do not ultimately succeed, which is why detailed research is particularly important. Understanding the science, the likelihood of regulatory approval and the potential commercial demand for a product can help investors make more informed decisions.

Balancing innovation with established healthcare businesses

CT Healthcare invests across a range of global healthcare companies. This can include earlier-stage businesses developing new treatments, as well as more established companies such as medical technology firms, hospitals and other healthcare providers. The aim is to participate in the long-term growth potential of healthcare innovation, while also maintaining exposure to businesses that may offer more steady growth characteristics.

Why specialist insight matters

A key feature of the approach is the team’s experience within the healthcare industry as well as in investment management. Portfolio Manager for CT Healthcare Trust, Kosta Kleyman, has worked inside leading healthcare companies, including Genentech, AstraZeneca and Arcus Biosciences. This practical experience helps the team assess areas such as clinical trial design, regulatory pathways and whether a product could become commercially successful.

This matters because healthcare investing often requires judgements that go beyond headline numbers. Specialist knowledge can help the team identify attractive opportunities, avoid weaker businesses and understand how larger healthcare companies may view potential acquisition targets.

The aim is not simply to invest in innovation, but to understand which innovations may have the strongest chance of becoming successful businesses.

A disciplined approach to a specialist sector

The trust’s approach is designed to reflect the different levels of risk across the healthcare sector. Higher-risk companies may be held in smaller positions, while more durable opportunities may have larger weightings. The trust’s absolute return focus means the team seeks to generate returns while carefully managing downside risk, rather than simply reflecting movements in the broader market. This disciplined approach is intended to help manage risk while giving investors exposure to the long-term potential of healthcare.

Investment risks

Capital at risk. The value of your investments and any income from them can go down as well as up and you may not get back the original amount invested.
Issued by Columbia Threadneedle Management Limited and approved for distribution 20/10/2026.
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26 October 2026

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